At the end of 2020, researchers at the University of Southern California and the National University of Singapore published in Cell Metabolism a paper entitled “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.” Their study found that that supplementing with the natural metabolite AKG (hence GeneAKG) significantly prolonged the lifespan and survival of mice, reduced their morbidity and inflammatory cytokines, greatly improved aging phenotypes such as coat color loss and hunchback development, and made the mice healthier. This is also the first in-depth study of the effects of CaAKG in mammals. Notably, Ca-AKG supplementation significantly increased the survival rate of female mice in the two experiments conducted. Compared with the control, Ca-AKG supplementation significantly prolonged the median life span and survival rate of female mice by 16.6% and 19.7%, respectively, in the first experiment, and by 10.5% and 8%, respectively, in the second experiment. Ca-AKG supplementation prolonged the median lifespan of male mice by 9.6% and 12.8%. Ca-AKG treatment significantly reduced the severity of various agedependent phenotypes such as loss of coat color, striated hair, dermatitis, an unstable gait, and a hunchback in female mice. In male mice, the physical condition, dermatitis, gait disturbance, eye discharge, kyphosis, and tumors were also improved. Importantly, no significant adverse effects of AKG treatment were found.